Endocrine Abstracts

Background: SEREN is an established, QISMET accredited structured education programme for children/young people (CYP) and their families with Type 1 diabetes mellitus (T1DM), developed in Wales. The first module ‘Diabetes at diagnosis’ has been in use in Wales since 2016. The resources and health care professional (HCP) training have also been used by some paediatric diabetes teams in England who have since embedded SEREN into their diabetes care. Th...

Background: Ramadan is the religious month in which Muslims fast from pre-dawn (suhoor) until sunset (iftar), abstaining from all kinds of food, and liquid. The major change in meal times may be challenging for hypothyroid patients on levothyroxine because levothyroxine has a narrow therapeutic index and should be taken on an empty stomach.Objective: We aim to compare pre- and post-Ramadan Thyroid function tests of hypothyroid patients taking levothyroxi...

Spontaneous pregnancy (SP) in TS is rare (4.8–7.6%). Oocyte-donation-in-vitro-fertilization (IVF-OD) and fertility-preservation increasingly offer the possibility of childbearing. Nevertheless, pregnancy is associated with an increased risk of complications. Adoption/surrogacy represents alternative parenting options.Aim: To analyse parenting options and pregnancy outcomes inTS.Methods: Data was collected in 154 TSwom...

Glioblastoma (GBM) is a highly aggressive form of brain cancer with a median survival time of 12–15 months from diagnosis. Standard therapies utilise a combination of radiotherapy, chemotherapy, and surgery. Patients also receive high doses of the potent anti-inflammatory glucocorticoid (Gc), Dexamethasone (Dex).Recent studies show that patients receiving the highest dose of Dex also have reduced survival time. Defining pathways under Gc control relevant to GBM is necessa...

Background: Data examining HLA associations in Addison’s disease (AD) from South Africa (SA) are limited. We wished to determine the HLA in South African AD patients either positive or negative for 21 hydroxylase autoantibodies (21 OH-AA) and matched healthy controls, hypothesising that certain HLA alleles could predominate, but there may be differences from Western countries.Methods: SA patients (n=73) were enrolled as part of a nationwide...

Childhood obesity and its later progression to Type 2 Diabetes (T2DM) are known to be associated with sub-clinical inflammation; although the underlying cause for this is unclear. However, studies suggest that bacterial endotoxin (LPS) derived from commensal bacteria in the human gastrointestinal tract may contribute directly to sub-clinical inflammation. Human adipose tissue expresses toll like receptors that induce an inflammatory cascade in the presence of endotoxin. Hence,...

By exploiting the canonical function of the sodium iodide symporter (NIS), ablative radioiodide therapy is an effective treatment for thyroid cancer. However, a subset of patients are unable to accumulate sufficient radioiodide due to decreased expression and/or plasma membrane localisation of NIS. Radioiodide therapy has been proposed as a viable treatment for breast cancer, but is hampered by low levels of NIS membrane localisation. Currently, the regulation of NIS trafficki...

Worldwide, ˜300,000 new cases of differentiated thyroid cancer are reported per annum and thyroid cancer now represents the most rapidly increasing cancer in the US and in the UK. In general terms, outcome is good (10-year survival >90%). However, up to 25% of patients develop local or regional recurrences, and have a significantly reduced life expectancy. We hypothesise those thyroid tumours which subsequently recur display a distinct pattern of driver ...

By exploiting the canonical function of the sodium iodide symporter (NIS), ablative radioiodide therapy is an effective treatment for thyroid cancer. However, a subset of patients are unable to accumulate sufficient radioiodide due to decreased expression and/or plasma membrane localisation of NIS. Radioiodide therapy has been proposed as a viable treatment for breast cancer, but is hampered by low levels of NIS membrane localisation. Currently, the regulation of NIS trafficki...

Worldwide, ˜300,000 new cases of differentiated thyroid cancer are reported per annum and thyroid cancer now represents the most rapidly increasing cancer in the US and in the UK. In general terms, outcome is good (10-year survival >90%). However, up to 25% of patients develop local or regional recurrences, and have a significantly reduced life expectancy. We hypothesise those thyroid tumours which subsequently recur display a distinct pattern of driver ...